Abstract |
Under the assumption that in some patients with refractory anemia with excess of blasts ( RAEB), the abnormal clones might be less responsive to granulocyte colony-stimulating factor than normal clones, the authors tried alternation therapy with a recombinant form of this factor (rhG-CSF) and antileukemic agents in the treatment of two patients with RAEB in transformation. After repetition of the short-cycled alternation therapy, the hematologic findings of both patients were completely normalized and have remained so without any adverse side effects under the continuation of this therapy for more than 5 months. Judging from our clinical experience, the alternation therapy may be a new efficient therapeutic strategy for RAEB and some types of slowly progressive leukemia.
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Authors | S Irie, H Ogura, S Okamoto, A Tojo, K Tani, K Ikebuchi, N Satoh, K Ozawa, S Asano |
Journal | The American journal of the medical sciences
(Am J Med Sci)
Vol. 303
Issue 5
Pg. 316-8
(May 1992)
ISSN: 0002-9629 [Print] United States |
PMID | 1374583
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Antineoplastic Agents
- Cytarabine
- Granulocyte Colony-Stimulating Factor
- Etoposide
- Daunorubicin
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Topics |
- Adult
- Anemia, Refractory, with Excess of Blasts
(drug therapy)
- Antineoplastic Agents
(administration & dosage)
- Cytarabine
(administration & dosage)
- Daunorubicin
(administration & dosage)
- Drug Administration Schedule
- Etoposide
(administration & dosage)
- Female
- Granulocyte Colony-Stimulating Factor
(administration & dosage)
- Humans
- Male
- Middle Aged
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