Human T lymphotropic virus types I- and II-specific antibody-dependent cellular cytotoxicity: strain specificity and epitope mapping.

Abstract	Antibody-dependent cellular cytotoxicity (ADCC) against human T lymphotropic virus (HTLV) types I and II was investigated using sera obtained from infected individuals or from rabbits immunized with HTLV-I or -II envelope peptides. Target cells included an HTLV-I-transformed cell line (C91/PL), an HTLV-II-transformed cell line (729pH6neo), and Epstein Barr virus (EBV)-transformed B lymphocytes expressing HTLV-I or -II env or gag gene products after infection with vaccinia/HTLV recombinants. ADCC activity was directed at HTLV-I and -II envelope glycoproteins but not against core (gag) components. In contrast to the human immunodeficiency virus system, significant cross-reactivity between HTLV-I- and -II-directed ADCC activity was observed. Epitope mapping studies using sera from rabbits that had been immunized with HTLV-I or -II envelope peptides suggested that the critical epitopes for ADCC activity are located primarily in hydrophilic regions of the exterior (gp46) part of the envelope glycoprotein.
Authors	X Q Zhang, L Yang, D D Ho, D R Kuritzkes, I S Chen, W T Ching, Y M Chen, R T Schooley
Journal	The Journal of infectious diseases (J Infect Dis) Vol. 165 Issue 5 Pg. 805-12 (May 1992) ISSN: 0022-1899 [Print] United States
PMID	1373751 (Publication Type: Journal Article)
Chemical References	Deltaretrovirus Antibodies Deltaretrovirus Antigens Epitopes Gene Products, env Gene Products, gag HTLV-I Antibodies HTLV-I Antigens HTLV-II Antibodies HTLV-II Antigens Immune Sera
Topics	Animals Antibody-Dependent Cell Cytotoxicity Cell Line, Transformed Cross Reactions Deltaretrovirus Antibodies (immunology) Deltaretrovirus Antigens (analysis) Epitopes (analysis) Fluorescent Antibody Technique Gene Products, env (immunology) Gene Products, gag (immunology) HTLV-I Antibodies (immunology) HTLV-I Antigens (analysis) HTLV-II Antibodies (immunology) HTLV-II Antigens (analysis) Human T-lymphotropic virus 1 (immunology) Human T-lymphotropic virus 2 (immunology) Humans Immune Sera (immunology) Rabbits Radioimmunoprecipitation Assay Species Specificity

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!