Abstract |
A 59-year-old woman was admitted to our hospital with acute onset of chest pain. She had experienced high fever, weight loss, polyarthralgia, myalgia, polyneuropathy and hallucinations for 3 years before admission. The diagnosis of polyarteritis nodosa with hepatitis B surface antigenemia was made by muscle biopsy and serological examinations, and administration of prednisolone induced remission of all the manifestations. After developing the acute attack of severe chest pain, she died suddenly. At autopsy, a DeBakey type 1 aortic dissection was found and the immediate cause of death was found to be cardiac tamponade secondary to rupture of the aortic dissection. Microscopically, necrotizing inflammatory lesions were present in the medium sized vascular arteries throughout her body. Furthermore, necrotizing vasculitis was also found in the vasa vasorum of the adventitia and media of the thoracic aorta. The dissecting lesion was seen in the outer layer of the media. Our results suggest that spontaneous dissection of the aorta may be attributed to necrotizing vasculitis of the vasa vasorum.
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Authors | T Iino, K Eguchi, M Sakai, S Nagataki, M Ishijima, K Toriyama |
Journal | The Journal of rheumatology
(J Rheumatol)
Vol. 19
Issue 10
Pg. 1632-6
(Oct 1992)
ISSN: 0315-162X [Print] Canada |
PMID | 1361205
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Aortic Dissection
(complications, etiology, pathology)
- Aortic Aneurysm, Thoracic
(complications, etiology, pathology)
- Autopsy
- Female
- Humans
- Middle Aged
- Necrosis
- Polyarteritis Nodosa
(complications, drug therapy, pathology)
- Prednisolone
(therapeutic use)
- Vasa Vasorum
(pathology)
- Vasculitis
(complications, diagnosis, pathology)
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