[Do calcium inhibitors have any role in secondary prevention of myocardial infarction?].

Abstract

The value of using calcium blockers in post-infarction secondary prevention is controversial. The HELD meta-analysis (1989) involving 17,759 patients concluded that they made no contribution in this indication (9.8% mortality rate vs 9.3% in the control group). The findings of the DAVIT II study with verapamil demonstrate a significant reduction in the infarction recurrence rate (18% vs 21.6%) in the treatment group. In the patients without heart failure, there was some benefit in terms of reduced mortality (7.7% vs 11.8%). The true contribution of calcium channel inhibitors, relative to that of beta-blockers in post-infarction medication should be analyzed in function of the various infarction sub-groups (no Q-wave, thrombolytic, with or without left ventricular dysfunction), of the calcium channel inhibitor being investigated and of the administration regimen.

• Authors: A Vacheron, X Tabone
• Journal: Annales de cardiologie et d'angeiologie (Ann Cardiol Angeiol (Paris)) Vol. 41 Issue 6 Pg. 343-7 (Jun 1992) ISSN: 0003-3928 [Print] France
• Vernacular Title: Les inhibiteurs calciques ont-ils une place dans la prévention secondaire de l'infarctus du myocarde?
• PMID: 1359828 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Adrenergic beta-Antagonists
• Calcium Channel Blockers

Topics

• Adrenergic beta-Antagonists (therapeutic use)
• Calcium Channel Blockers (therapeutic use)
• Clinical Trials as Topic (methods)
• Humans
• Meta-Analysis as Topic
• Myocardial Infarction (epidemiology, prevention & control)
• Recurrence