Abstract |
Preliminary data from an ongoing epidemiological survey in the pastoral zone of Samorogouan (Kénédougou) indicate the occurrence of multiple- drug-resistant Trypanosoma congolense. Despite frequent trypanocidal drug treatments with diminazene aceturate ( Berenil, Hoechst) at 7 mg/kg body weight (bw) at intervals of 2 to 4 weeks, no significant drop in the prevalence of African animal trypanosomosis (AAT) was observed. To examine a suspected drug resistance, 20 Zebu cattle, naturally infected with T. congolense and/or T. vivax, were transferred in December 1989 from Samorogouan into a fly-proof stable. Diminazene aceturate at 7 mg/kg bw cured infections of T. vivax, but was ineffective against T. congolense. Likewise, treatments with homidium bromide ( Ethidium, FBC) at 1 mg/kg bw and isometamidium chloride ( Trypamidium, Rhône Mérieux) at 1 mg/kg bw, respectively, proved to be ineffective. Corresponding chemotherapeutic trials in previously unexposed Zebu bulls and Sahelian goats infected with one primary T. congolense isolate from Samorogouan demonstrated a high level of resistance to diminazene aceturate (7 mg/kg bw in cattle and 17.5 mg/kg bw in goats), isometamidium chloride (1 and 2 mg/kg bw i.v. in goats) and quinapyramine sulphate (Trypacide'S', Rhône Mérieux) at 5 mg/kg bw in goats. The appearance of a multiple- drug-resistant strain of T. congolense emphasizes the urgent need for new chemical substances as trypanocidal drugs and the increasing importance of efficient vector control.
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Authors | P H Clausen, I Sidibe, I Kaboré, B Bauer |
Journal | Acta tropica
(Acta Trop)
Vol. 51
Issue 3-4
Pg. 229-36
(Aug 1992)
ISSN: 0001-706X [Print] Netherlands |
PMID | 1359750
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Trypanocidal Agents
- diminazene aceturate
- Diminazene
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Topics |
- Animals
- Burkina Faso
(epidemiology)
- Cattle
(parasitology)
- Diminazene
(analogs & derivatives, pharmacology, therapeutic use)
- Drug Resistance
- Prevalence
- Recurrence
- Trypanocidal Agents
(pharmacology, therapeutic use)
- Trypanosoma congolense
(drug effects, isolation & purification)
- Trypanosomiasis, African
(drug therapy, epidemiology, parasitology, veterinary)
- Trypanosomiasis, Bovine
(drug therapy, epidemiology, parasitology)
- Tsetse Flies
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