Parathyroid carcinoma in a patient with non-secretory pituitary tumor: a variant of multiple endocrine neoplasia type-I?

Abstract

We report a case of pituitary adenoma in association with parathyroid carcinoma as an unusual combination of multiple endocrine neoplasia (MEN). A 48-year-old man had a trans-sphenoidal hypophysectomy and transcranial partial removal of a recurrent pituitary chromophobe adenoma followed by a course of radiotherapy in 1980. Four years later, he developed hypercalcemic crisis from a parathyroid carcinoma with invasion to the adjacent thyroid gland and skeletal muscle. A hemithyroidectomy and resection of the left lower parathyroid gland was performed. Three years later, he had local recurrence and anterior chest wall metastasis accompanied by hypercalcemia. After resection of the remnant and metastatic lesion, eucalcemia was achieved. There was no family history of endocrine tumors. This case illustrates the rare association of a malignant parathyroid tumor and a chromophobe adenoma of the pituitary as a variant of MEN syndrome.

• Authors: C W Wu, C I Huang, S T Tsai, H Chiang, W Y Lui, F K P'eng
• Journal: European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology (Eur J Surg Oncol) Vol. 18 Issue 5 Pg. 517-20 (Oct 1992) ISSN: 0748-7983 [Print] England
• PMID: 1358678 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Adenoma, Chromophobe (metabolism, pathology, surgery)
• Adult
• Carcinoma (complications, pathology, surgery)
• Humans
• Hypercalcemia (etiology)
• Male
• Multiple Endocrine Neoplasia
• Parathyroid Neoplasms (complications, pathology, surgery)
• Pituitary Neoplasms (metabolism, pathology, surgery)