Schizophrenia and porphobilinogen deaminase gene polymorphisms: an association study.

Abstract

A genetic case-control study was conducted in a group of patients with schizophrenia (n = 67; DSM-III) and psychiatrically normal controls matched for ethnicity (n = 84), living in the same geographical area. Using three different DNA polymorphisms of the gene encoding porphobilinogen deaminase (PBGD), a candidate gene for schizophrenia, an association with schizophrenia could not be detected. No significant associations were detected even after sub-division of the cohort by ethnicity and by gender.

• Authors: V L Nimgaonkar, R Ganguli, S S Washington, A Chakravarti
• Journal: Schizophrenia research (Schizophr Res) Vol. 8 Issue 1 Pg. 51-8 (Oct 1992) ISSN: 0920-9964 [Print] Netherlands
• PMID: 1358185 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• DNA
• Hydroxymethylbilane Synthase

Topics

• Adult
• Alleles
• Chromosome Mapping
• Cohort Studies
• DNA (genetics)
• Female
• Genotype
• Humans
• Hydroxymethylbilane Synthase (genetics)
• Male
• Middle Aged
• Polymerase Chain Reaction
• Polymorphism, Restriction Fragment Length
• Risk Factors
• Schizophrenia (diagnosis, genetics)
• Schizophrenic Psychology