Effect of H1-receptor blockade on anthralin inflammation.

Abstract

The effect of terfenadine, an H1-receptor antagonist, on anthralin inflammation was studied in 12 subjects. Subjects were randomised to receive terfenadine 60 mg or placebo b.d. in a double-blind, cross-over study. Anthralin 5, 10 and 20 micrograms in 10 microliters chloroform was pipetted onto flexor forearm skin. Anthralin inflammatory oedema and erythema were measured using Harpenden calipers and a reflectance photometer, 48 h after anthralin application. After a 3-day washout period, placebo and terfenadine were restarted and the procedures repeated on the opposite arm. Anthralin erythema and oedema increased with dose but the dose-response curves showed no significant difference with or without terfenadine (p greater than 0.05). This study shows that H1-receptor blockade does not inhibit anthralin inflammation.

• Authors: E L Speight, B Ramsay, C M Lawrence
• Journal: Skin pharmacology : the official journal of the Skin Pharmacology Society (Skin Pharmacol) Vol. 5 Issue 1 Pg. 25-8 ( 1992) ISSN: 1011-0283 [Print] Switzerland
• PMID: 1349488 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Histamine H1 Antagonists
• Terfenadine
• Anthralin

Topics

• Adult
• Aged
• Anthralin (adverse effects)
• Dermatitis (prevention & control)
• Dose-Response Relationship, Drug
• Double-Blind Method
• Female
• Histamine H1 Antagonists (therapeutic use)
• Humans
• Male
• Middle Aged
• Terfenadine (therapeutic use)