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Anti-GOR and hepatitis C virus in autoimmune liver diseases.

Abstract
Anti-GOR is an autoantibody found in hepatitis C virus (HCV) infection. We have studied the specificity of this antibody for HCV infection in various groups of autoimmune liver diseases. Anti-HCV was detected by a second generation HCV enzyme-linked immunosorbent assay in 14 of 29 patients with liver-kidney-microsomal (LKM-1) -antibody-positive autoimmune hepatitis type 2 and in all 6 control patients with HCV-RNA-positive chronic hepatitis C. Anti-HCV was not found in those with antinuclear-antibody-positive autoimmune hepatitis type 1 (10 patients), with soluble-liver-protein-antibody-positive autoimmune hepatitis type 3 (8), with primary biliary cirrhosis (9), with systemic lupus erythematosus (SLE) (10), or in healthy controls (13). Anti-GOR was detected in 11 of 14 patients with autoimmune hepatitis type 2 who were all positive for anti-HCV but only in 1 of 15 LKM-1 patients who were negative for anti-HCV. We did not find anti-GOR in any other group of autoimmune liver disease, SLE, or control sera, but this antibody was detected in 3 of 6 patients with chronic hepatitis C. Autoimmune hepatitis type 2 patients who were anti-GOR positive and anti-HCV positive were less likely to be female, were older (p less than 0.001), and had lower LKM-1 antibody titres (p less than 0.001), lower disease activity, and responded less effectively to immuno- suppression than did those who were anti-HCV negative/anti-GOR negative. The findings show that anti-GOR reflects HCV-specific autoimmunity. HCV seems to induce autoimmunity to both GOR (an HCV-specific autoepitope) and LKM-1 (an epitope that is also recognised by autoimmune hepatitis sera of a different cause). Anti-GOR and LKM-1 antibodies contribute to a better differentiation of chronic hepatitis, a finding that has therapeutic implications.
AuthorsG Michel, A Ritter, G Gerken, K H Meyer zum Büschenfelde, R Decker, M P Manns
JournalLancet (London, England) (Lancet) Vol. 339 Issue 8788 Pg. 267-9 (Feb 01 1992) ISSN: 0140-6736 [Print] England
PMID1346282 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Autoantibodies
  • Hepatitis Antibodies
Topics
  • Adolescent
  • Adult
  • Age Factors
  • Aged
  • Autoantibodies (analysis)
  • Autoimmune Diseases (immunology)
  • Child
  • Child, Preschool
  • Female
  • Hepacivirus (immunology)
  • Hepatitis Antibodies (analysis)
  • Hepatitis C (immunology)
  • Hepatitis, Chronic (immunology)
  • Humans
  • Immunosuppression Therapy
  • Male
  • Microsomes, Liver (immunology)
  • Middle Aged
  • Retrospective Studies
  • Sex Factors

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