Ciprofloxacin for treatment of malakoplakia.

Abstract

The tumour-like lesions of the rare disease malakoplakia, which consist of macrophages containing undigested coliform bacteria, are often misdiagnosed as a carcinoma. Although an infectious aetiology is likely, no antimicrobial therapy has been successful in the long-term. Since ciprofloxacin penetrates well into macrophages, this drug was given to two patients with advanced malakoplakia (500 mg twice daily). After long-term treatment all granulomatous lesions disappeared. Thus, malakoplakia can be cured by antibiotic treatment.

• Authors: R van Furth, J W van't Wout, P A Wertheimer, J Zwartendijk
• Journal: Lancet (London, England) (Lancet) Vol. 339 Issue 8786 Pg. 148-9 (Jan 18 1992) ISSN: 0140-6736 [Print] England
• PMID: 1346012 (Publication Type: Case Reports, Journal Article)

Chemical References

• Ciprofloxacin

Topics

• Adult
• Ciprofloxacin (therapeutic use)
• Combined Modality Therapy
• Escherichia coli Infections (drug therapy, surgery)
• Female
• Humans
• Macrophages (drug effects, microbiology)
• Malacoplakia (drug therapy, surgery)
• Middle Aged
• Nephrectomy
• Ureteral Diseases (drug therapy, surgery)
• Urinary Bladder Diseases (drug therapy, surgery)