[The immunomodulating role of indomethacin in the chemoradiation treatment of inoperable patients with lung cancer].

Abstract

The immunocorrective effect of indomethacin in the course of chemoradiation treatment for inoperable lung cancer was established in a group of 117 patients. It manifested itself in an increase in T-lymphocyte level, normalization of their membrane structure and improvement in immunoregulatory function mainly due to a rise in T-helper/inductor level. Blood plasma-circulating immune complex concentration returned to normal. The concomitant administration of indomethacin during chemoradiation therapy improved subjective status of patients and tumor response but failed to increase survival.

• Authors: I V Kas'ianenko, V M Pivniuk, A M Lisitsa, N A Kovalenko, M A Bagirian
• Journal: Voprosy onkologii (Vopr Onkol) Vol. 38 Issue 10 Pg. 1183-7 ( 1992) ISSN: 0507-3758 [Print] Russia (Federation)
• Vernacular Title: Immunomoduliatornaia rol' indometatsina pri khimioluchevom lechenii neoperabel'nykh bol'nykh rakom legkogo.
• PMID: 1343143 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Adjuvants, Immunologic
• Indomethacin

Topics

• Adenocarcinoma (drug therapy, pathology, radiotherapy)
• Adjuvants, Immunologic (therapeutic use)
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Carcinoma, Small Cell (drug therapy, immunology, pathology, radiotherapy)
• Carcinoma, Squamous Cell (drug therapy, immunology, pathology, radiotherapy)
• Combined Modality Therapy
• Humans
• Indomethacin (therapeutic use)
• Lung Neoplasms (drug therapy, immunology, pathology, radiotherapy)
• Neoplasm Staging
• Remission Induction
• T-Lymphocytes (drug effects, immunology)