Hepatitis B vaccine--proposal for a standardized assessment of immune response.

Abstract

The authors developed a comparative study of the various methods of assessment of immune response to Hepatitis B vaccine. Eighty-six health care professionals underwent a vaccination programme with three doses of plasma-derived vaccine against Hepatitis B (H-B-Vax, Merck, Sharp & Dohme) given intramuscularly. Assessment of immune response was carried out three months after the end of the programme, by radioimmunoassay (RIA) and enzyme immunoassay (EIA). The results showed that the semi-quantitative assessment of Anti-HBs antibodies by RIA or EIA was perfectly comparable to the reference method (quantitative determination of antibodies by RIA). In view of these findings, the authors suggest a standardization of assessment of immune response to the vaccine, thus permitting correct planning of booster doses and easier comparison between different studies.

• Authors: M L Ferraz, A E Silva, M Yamamoto, R X Guimaråes
• Journal: Revista do Instituto de Medicina Tropical de Sao Paulo (Rev Inst Med Trop Sao Paulo) 1992 Mar-Apr Vol. 34 Issue 2 Pg. 137-40 ISSN: 0036-4665 [Print] Brazil
• PMID: 1340027 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Hepatitis B Antibodies
• Hepatitis B Vaccines
• Histocompatibility Antigens Class II

Topics

• Adolescent
• Adult
• Female
• Hepatitis B Antibodies (analysis, immunology)
• Hepatitis B Vaccines (immunology, standards)
• Histocompatibility Antigens Class II (immunology)
• Humans
• Immunoenzyme Techniques
• Male
• Middle Aged
• Radioimmunoassay
• Time Factors