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Enhancement of effector cell activities in mice bearing syngeneic plasmacytoma X5563 by a biological response modifier, PSK.

Abstract
We investigated the effect of PSK, a protein-bound polysaccharide obtained from Coriolus versicolor of basidiomycetes, on antitumor immunity in tumor-bearing mice. PSK prolonged significantly the life span of C3H/He mice bearing syngeneic plasmacytoma X5563 in a schedule- and dose-dependent manner. PSK was most effective when administered at 100 mg/kg every other day ten times starting from the day after tumor inoculation. The administration of PSK enhanced significantly the cytostatic activity of peritoneal exudate plastic-adherent cells and the cytolytic activity of spleen cells after in vitro incubation with mitomycin C-treated tumor cells. In addition, PSK restored the cytokine-producing capacity of spleen cells suppressed in tumor-bearing mice after in vitro incubation with mitogen. Sera from tumor-bearing mice suppressed the activity of such effector cells as well as the interleukin 2-producing capacity of spleen cells, but sera from PSK-treated tumor-bearing mice prevented this suppression. These results suggest that PSK enhances antitumor immunity by reducing immunosuppressive activity of serum from tumor-bearing mice.
AuthorsK Matsunaga, H Iijima, M Aota, Y Oguchi, T Fujii, C Yoshikumi, K Nomoto
JournalJournal of clinical & laboratory immunology (J Clin Lab Immunol) Vol. 37 Issue 1 Pg. 21-37 (Jan 1992) ISSN: 0141-2760 [Print] Scotland
PMID1339233 (Publication Type: Journal Article)
Chemical References
  • Adjuvants, Immunologic
  • Cytokines
  • Immunologic Factors
  • Proteoglycans
  • polysaccharide-K
Topics
  • Adjuvants, Immunologic (pharmacology, therapeutic use)
  • Animals
  • Ascites (pathology)
  • Cytokines (metabolism)
  • Cytotoxicity, Immunologic (drug effects)
  • Dose-Response Relationship, Drug
  • Female
  • Immunologic Factors (pharmacology, therapeutic use)
  • Lymphocyte Activation (drug effects)
  • Mice
  • Mice, Inbred C3H (immunology)
  • Neoplasm Transplantation
  • Plasmacytoma (immunology, therapy)
  • Proteoglycans (pharmacology, therapeutic use)
  • Spleen (pathology)
  • T-Lymphocyte Subsets (drug effects, metabolism)

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