Abstract |
We investigated the effect of PSK, a protein-bound polysaccharide obtained from Coriolus versicolor of basidiomycetes, on antitumor immunity in tumor-bearing mice. PSK prolonged significantly the life span of C3H/He mice bearing syngeneic plasmacytoma X5563 in a schedule- and dose-dependent manner. PSK was most effective when administered at 100 mg/kg every other day ten times starting from the day after tumor inoculation. The administration of PSK enhanced significantly the cytostatic activity of peritoneal exudate plastic-adherent cells and the cytolytic activity of spleen cells after in vitro incubation with mitomycin C-treated tumor cells. In addition, PSK restored the cytokine-producing capacity of spleen cells suppressed in tumor-bearing mice after in vitro incubation with mitogen. Sera from tumor-bearing mice suppressed the activity of such effector cells as well as the interleukin 2-producing capacity of spleen cells, but sera from PSK-treated tumor-bearing mice prevented this suppression. These results suggest that PSK enhances antitumor immunity by reducing immunosuppressive activity of serum from tumor-bearing mice.
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Authors | K Matsunaga, H Iijima, M Aota, Y Oguchi, T Fujii, C Yoshikumi, K Nomoto |
Journal | Journal of clinical & laboratory immunology
(J Clin Lab Immunol)
Vol. 37
Issue 1
Pg. 21-37
(Jan 1992)
ISSN: 0141-2760 [Print] Scotland |
PMID | 1339233
(Publication Type: Journal Article)
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Chemical References |
- Adjuvants, Immunologic
- Cytokines
- Immunologic Factors
- Proteoglycans
- polysaccharide-K
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Topics |
- Adjuvants, Immunologic
(pharmacology, therapeutic use)
- Animals
- Ascites
(pathology)
- Cytokines
(metabolism)
- Cytotoxicity, Immunologic
(drug effects)
- Dose-Response Relationship, Drug
- Female
- Immunologic Factors
(pharmacology, therapeutic use)
- Lymphocyte Activation
(drug effects)
- Mice
- Mice, Inbred C3H
(immunology)
- Neoplasm Transplantation
- Plasmacytoma
(immunology, therapy)
- Proteoglycans
(pharmacology, therapeutic use)
- Spleen
(pathology)
- T-Lymphocyte Subsets
(drug effects, metabolism)
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