Prospective study on the diagnosis of hepatocellular carcinoma by using alpha-fetoprotein reactive to lentil lectin.

Abstract

In order to study the changes in AFP reactive to lentil lectin (AFP-R-L) during the development of hepatocellular carcinoma (HCC) and its clinical significance, AFP-R-L was monitored in 64 patients by using 20-400 ng/L AFP and negative imaging localization. AFP-R-L was determined by using affino-crossed-immunoelectrophoresis autoradiography. AFP-R-L above 25% was considered positive for the diagnosis of HCC. Over a follow-up of 3-31 months, 32 patients developed HCC. The positivity of AFP-R-L was 59.4% in the HCC group at the first assay. The accuracy of using positive AFP-R-L values to predict HCC was 95.0%. Increased AFP-R-L levels appeared 3-24 months earlier than did positive imaging location. The results suggest that positive AFP-R-L values can predict the development of HCC.

• Authors: Z Tu, Z Yin, M Wu
• Journal: Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih (Chin Med Sci J) Vol. 7 Issue 4 Pg. 191-6 (Dec 1992) ISSN: 1001-9294 [Print] China
• PMID: 1339156 (Publication Type: Journal Article)

Chemical References

• Biomarkers, Tumor
• Lectins
• Plant Lectins
• lentil lectin
• Adenosine Triphosphate

Topics

• Adenosine Triphosphate (metabolism)
• Adult
• Aged
• Autoradiography (methods)
• Biomarkers, Tumor (blood)
• Carcinoma, Hepatocellular (diagnosis)
• Female
• Humans
• Immunoelectrophoresis, Two-Dimensional
• Lectins (metabolism)
• Liver Neoplasms (diagnosis)
• Male
• Middle Aged
• Plant Lectins
• Prospective Studies