[Gastric emptying and metabolic acidosis. III. Study of gastric retention of a sodium citrate solution using an experimental model of metabolic acidosis in rats].

Abstract

The gastric emptying of sodium citrate solution 0.25 mEq/ml was studied in rats with metabolic acidosis induced by orogastric infusion of 0.5 M ammonium chloride solution. Two control groups were used: one infused with 0.5 M sodium chloride and the other with water. The 3 solutions content was 2 ml/100 g weight of the animal. Six hours after the infusion, there was a moderate metabolic acidosis in the group with ammonium citrate. This 6 hour interval marked the beginning of the gastric emptying study. The test meal (sodium citrate 0.25 mEq/ml) was utilized containing 6 mg% red fenol as a marker. The gastric emptying of sodium citrate was studied at 5, 10, 20 and 30 minutes after the infusion, and the results showed no differences between the 3 groups. The data suggest that the duodenal receptors to pH were more effective do determine the pattern of gastric response than the acidosis.

• Authors: E C Baracat, E F Collares
• Journal: Arquivos de gastroenterologia (Arq Gastroenterol) 1992 Jul-Sep Vol. 29 Issue 3 Pg. 101-5 ISSN: 0004-2803 [Print] Brazil
• Vernacular Title: Esvaziamento gástrico e acidose metabólica. III. Estudo da retenção gástrica de uma soluçao de citrato de sódio, utilizando um modelo experimental de acidose metabólica em ratos.
• PMID: 1339143 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Bicarbonates
• Citrates
• Ammonium Chloride
• Citric Acid
• Sodium Bicarbonate
• Sodium

Topics

• Acid-Base Equilibrium (drug effects, physiology)
• Acidosis (blood, chemically induced, metabolism)
• Ammonium Chloride
• Animals
• Bicarbonates (blood)
• Citrates (metabolism)
• Citric Acid
• Disease Models, Animal
• Female
• Gastric Emptying
• Rats
• Rats, Wistar
• Sodium (blood)
• Sodium Bicarbonate