Abstract |
We searched for HPV DNA in 72 cases of seborrheic keratosis (nongenital SK 29, genital SK 43) using polymerase chain reaction. Amplification of HPV DNA was found in 24 (nongenital, 1; genital, 23). HPV DNA type 6 was present in 18 cases and type 11 in four and type 33 in two. Twenty-three (53%) cases of genital region SK and one (3%) case of nongenital region SK contained HPV DNA sequences. Histopathologically, the perinuclear vacuolization of epithelial cells, mitosis and dyskeratotic cells were more marked in HPV DNA-positive SK than those in negative SK (P < 0.01). We suppose HPV may play an important role in epidermal proliferation of SK in the genital region.
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Authors | W Y Zhu, C Leonardi, N S Penneys |
Journal | Journal of dermatological science
(J Dermatol Sci)
Vol. 4
Issue 3
Pg. 166-71
(Nov 1992)
ISSN: 0923-1811 [Print] Netherlands |
PMID | 1337468
(Publication Type: Journal Article)
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Chemical References |
- DNA Probes, HPV
- DNA, Viral
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Base Sequence
- DNA Probes, HPV
- DNA, Viral
(genetics, isolation & purification)
- Female
- Genitalia
(microbiology)
- Humans
- Keratosis, Seborrheic
(microbiology, pathology)
- Male
- Middle Aged
- Molecular Sequence Data
- Papillomaviridae
(genetics, isolation & purification)
- Polymerase Chain Reaction
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