[Myocardial beta-adrenergic receptors and left ventricular hypertrophy induced by pressure overload in man].

Abstract

In experimental models, the characteristics of beta-adrenoceptors in left ventricular hypertrophy (LVH) due to pressure overload remain controversial and no data are still available in man. We investigated right auricular (RA) and left ventricular (LV) beta-adrenoceptors characteristics (125 I cyanopindolol binding) in two groups of patients undergoing valve replacement without heart failure (LV ejection fraction > 55%). Height patients with mitral stenosis (mean age: 64 +/- 4 years) and without LVH (LV mass index < 120 g/m2) constituted the control group and 13 patients with aortic stenosis (mean age: 66 +/- 4 years) and LVH (LV mass index > 150 g/m2) the study group. The results are: [table: see text] These results show that, in man, LVH due to pressure overload does not induce variation of total number beta-adrenoceptors, but is associated with a selective decrease in left ventricular beta 1-adrenoceptors.

• Authors: M Galinier, J M Sénard, G Dréan, P Valet, Y Glock, P Dalous, D Roux, J Puel, J L Montastruc, J P Bounhoure
• Journal: Archives des maladies du coeur et des vaisseaux (Arch Mal Coeur Vaiss) Vol. 85 Issue 8 Pg. 1113-7 (Aug 1992) ISSN: 0003-9683 [Print] France
• Vernacular Title: Récepteurs bêta-adrénergiques myocardiques et hypertrophie ventriculaire gauche induite par une surcharge barométrique chez l'homme.
• PMID: 1336354 (Publication Type: English Abstract, Journal Article)

Chemical References

• Catecholamines
• Receptors, Adrenergic, beta

Topics

• Aged
• Catecholamines (blood)
• Down-Regulation
• Female
• Humans
• Hypertension (physiopathology)
• Hypertrophy, Left Ventricular (physiopathology)
• Male
• Middle Aged
• Myocardium (metabolism)
• Receptors, Adrenergic, beta (analysis)
• Sympathetic Nervous System (physiopathology)