[The effect of the delta sleep-inducing peptide on seizure activity].

Abstract

The delta-sleep-inducing peptide (DSIP) suppressed seizure activity in the cat cortical strychnine-induced seizure foci. The DSIP delayed development of corazol kindling in rats, prevented seizure induced with bicucullin and other agents in mice. The DSIP effect was shown to be realised through the action upon reticular black substance. The DSIP seems to take part in endogenous control of the brain excitability.

• Authors: A A SHandra, L S Godlevskiĭ, A M Mazarati, A A Oleshko, I I Mikhaleva
• Journal: Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova (Fiziol Zh SSSR Im I M Sechenova) Vol. 78 Issue 5 Pg. 17-23 (May 1992) ISSN: 0015-329X [Print] Russia (Federation)
• Vernacular Title: Vliianie del'ta-son-indutsiruiushchego peptida na sudorozhnuiu aktivnost'.
• PMID: 1334876 (Publication Type: English Abstract, Journal Article)

Chemical References

• Delta Sleep-Inducing Peptide

Topics

• Animals
• Brain Chemistry (drug effects)
• Cats
• Delta Sleep-Inducing Peptide (administration & dosage, analysis, therapeutic use)
• Drug Evaluation, Preclinical
• Electroencephalography (drug effects)
• Kindling, Neurologic (drug effects, physiology)
• Male
• Mesencephalon (chemistry, drug effects)
• Mice
• Mice, Inbred C57BL
• Mice, Inbred CBA
• Rats
• Rats, Wistar
• Seizures (chemically induced, drug therapy, metabolism)
• Time Factors