Clinical findings and lysosomal
enzymes (
LYE) in eight
lumpy skin diseases (
LSD) cows and same number of healthy ones were reported in Tal-El Baker village and Tal Alkabir centre, Ismailia province, Egypt.
LSD began with
fever,
anorexia, skin lesions in form of nodules all over the body, which disappeared spontaneously or gathered to form large lumps. It was complicated with respiratory manifestation,
corneal opacity,
mastitis,
dehydration and later on recumbency. It is noteworthy that the level of 3
LYE showed the same trend of significant reduction in acute stage of the disease (5 days after occurrence of
LSD) probably due to injection of animals with a
therapeutics dose of
terramycin.
Acid-phosphatase (ACP)
enzyme is the sole that behaved very high significant increase in the serum in acute stage of
LSD due to the damaged tissues caused by the virus. It underwent insignificant decrease in late stage of the disease (20 days after its occurrence) to restore the normal
LYE level in control cows indicating recovery.
Alpha-galactosidase (alpha-GAL) decreased perpetually by the progression of
LSD because of the decreased bactericidal index which ist in concomitance with the secondary bacterial invader. N-acetyl-beta-
glucosaminidase (beta-NAG) and
beta-galactosidase (beta-GAL) in
LYE had the same fluctuating manner. The activities showed very highly significant decrease in acute stage, followed by highly significant and significant increases (late
LSD stage) respectively. The appreciable significant increase of beta-GAL may declare the effect of
anorexia on
LSD. In view of these findings, it can be postulated that
LSD may be diagnosed and prognosed through
LYE changes in the serum.