Abstract |
Eight kinds of neuropeptides and four kinds of neuropeptide receptors were examined in the right and left hemispheres of mongolian gerbils after unilateral carotid ligation-induced stroke and in normal controls. Five hours after ligation of the right common carotid artery, beta-endorphin concentration in the right hemisphere (ischemic side) of the stroke group was significantly increased compared with that in the contralateral hemisphere (non-ischemic side), but there were no differences between sides in other neuropeptides either with or without stroke. Furthermore, although there were no differences in [3H] naloxone binding, [3H] thyrotropin-releasing hormone binding or 125I-vasoactive intestinal polypeptide binding in the brain in this model of stroke, [3H] enkephalin binding was significantly lower on the ischemic side than on the non-ischemic side in the stroke group. These results suggest that increased activity in the beta-endorphinergic system in the brain might be partly caused by ischemic brain failure.
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Authors | K Haba, N Ogawa, M Asanuma, H Hirata, Y H Sora, A Mori |
Journal | Journal of the neurological sciences
(J Neurol Sci)
Vol. 108
Issue 1
Pg. 88-92
(Mar 1992)
ISSN: 0022-510X [Print] Netherlands |
PMID | 1320663
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Endorphins
- Neuropeptides
- Receptors, Neurotransmitter
- Receptors, Opioid
- Naloxone
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Topics |
- Animals
- Brain Chemistry
- Cerebral Infarction
(metabolism)
- Endorphins
(metabolism)
- Gerbillinae
- Naloxone
(metabolism)
- Neuropeptides
(analysis)
- Receptors, Neurotransmitter
(analysis)
- Receptors, Opioid
(metabolism)
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