Clinical effects and in vitro studies of trifluorothymidine combined with interferon-alpha for treatment of drug-resistant and -sensitive herpes simplex virus infections.

Abstract	Three AIDS patients with severe cutaneous herpes simplex virus (HSV) infection refractory to therapy with acyclovir and foscarnet (2 patients) were treated with a topical preparation of trifluorothymidine (TFT) and interferon-alpha. Complete healing of lesions occurred in 1 patient; a second had significant regression of the infected area. In the third, the lesion was stabilized twice after application of the preparation and reduced in size after a subsequent treatment. In vitro studies confirmed that isolates from these patients were acyclovir- or acyclovir/foscarnet-resistant. In addition, they revealed strong synergy between TFT and interferon-alpha for these isolates and for strains with wild-type drug sensitivity profiles. Topical TFT/interferon-alpha may be of benefit in the therapy of mucocutaneous HSV infections, especially when they are resistant to treatment with systemic antiviral agents.
Authors	C J Birch, D P Tyssen, G Tachedjian, R Doherty, K Hayes, A Mijch, C R Lucas
Journal	The Journal of infectious diseases (J Infect Dis) Vol. 166 Issue 1 Pg. 108-12 (Jul 1992) ISSN: 0022-1899 [Print] United States
PMID	1318909 (Publication Type: Case Reports, Journal Article)
Chemical References	Antiviral Agents Interferon Type I Recombinant Proteins Foscarnet Phosphonoacetic Acid Trifluridine Acyclovir
Topics	Acquired Immunodeficiency Syndrome (complications) Acyclovir (pharmacology, therapeutic use) Adult Antiviral Agents (pharmacology, therapeutic use) Combined Modality Therapy Cytopathogenic Effect, Viral (drug effects) Dose-Response Relationship, Drug Drug Resistance, Microbial Female Foscarnet Herpes Simplex (complications, drug therapy, therapy) Humans Interferon Type I (pharmacology, therapeutic use) Male Phosphonoacetic Acid (analogs & derivatives, pharmacology, therapeutic use) Recombinant Proteins Recurrence Simplexvirus (drug effects) Trifluridine (pharmacology, therapeutic use) Virus Replication (drug effects)

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