Abstract |
The clonal growth of cell lines from some human solid tumours can be stimulated by haematopoietic growth factors such as recombinant human (rh) interleukin-3 (IL-3) and rh granulocyte-macrophage colony-stimulating factor ( GM-CSF) in vitro. Among these cell lines are the human colorectal adenocarcinoma cell line HTB 38 and the human small-cell lung cancer cell line HTB 119. Here we report on a series of experiments studying the influence of subcutaneously administered rhIL-3 and rhGM-CSF on the in vivo growth of HTB 38 and HTB 119 cell lines as xenografts in athymic nu/nu BALB/c mice. Beginning 1 day after transplantation of the tumour the cytokines were administered daily for 20 days as a subcutaneous bolus distant from the tumour lesion at dose levels up to 1 mg/m2/day. The cytokines caused no significant and reproducible growth modulation of the tumours in vivo.
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Authors | W E Berdel, M Zafferani, R Senekowitsch, E D Kreuser, E Thiel |
Journal | European journal of cancer (Oxford, England : 1990)
(Eur J Cancer)
Vol. 28
Issue 2-3
Pg. 377-80
( 1992)
ISSN: 0959-8049 [Print] England |
PMID | 1317197
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Interleukin-3
- Recombinant Proteins
- Granulocyte-Macrophage Colony-Stimulating Factor
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Topics |
- Adenocarcinoma
(pathology)
- Animals
- Carcinoma, Small Cell
(pathology)
- Cell Division
(drug effects)
- Cell Line
- Colorectal Neoplasms
(pathology)
- Granulocyte-Macrophage Colony-Stimulating Factor
(pharmacology)
- Humans
- Interleukin-3
(pharmacology)
- Lung Neoplasms
(pathology)
- Mice
- Mice, Nude
- Neoplasm Transplantation
- Recombinant Proteins
(pharmacology)
- Transplantation, Heterologous
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