Abstract |
We describe methods for using ameroid constrictors to develop renin-dependent hypertension in dogs. A vascular-access-port was implanted in each dog and mean arterial blood pressure was monitored. Via a small flank incision, an ameroid constrictor was placed on the left renal artery and mean arterial blood pressure, plasma renin activity, and the response to angiotensin-converting enzyme inhibition measured during the subsequent 4 weeks. Placement of the constrictor on the left renal artery resulted in a significant increase in plasma renin activity which was accompanied by a significant hypertension (blood pressure greater than 140 mmHg). The greatest increase in plasma renin activity and blood pressure occurred at week two which coincided with the greatest response to angiotensin-converting enzyme inhibition, when mean arterial blood pressure decreased more than 30 mmHg after administration of either captopril or enalapril (1 mg/kg, i.v.). The results of this study indicate that ameroid constrictors provide a reliable method for establishing renin-dependent hypertension in dogs.
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Authors | D P Brooks, T A Fredrickson |
Journal | Laboratory animal science
(Lab Anim Sci)
Vol. 42
Issue 1
Pg. 67-9
(Feb 1992)
ISSN: 0023-6764 [Print] United States |
PMID | 1316513
(Publication Type: Journal Article)
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Chemical References |
- Biocompatible Materials
- Caseins
- Hydrogels
- ameroid
- Renin
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Topics |
- Animals
- Biocompatible Materials
(adverse effects)
- Blood Pressure
(drug effects)
- Caseins
- Constriction
- Disease Models, Animal
- Dogs
- Heart Rate
(drug effects)
- Hydrogels
- Hypertension, Renal
(blood, etiology)
- Male
- Renal Artery
(surgery)
- Renin
(blood, drug effects, physiology)
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