Abstract |
This paper reports a case of pancreatic VIPoma with widespread hepatic metastasis which was treated for approximately 2 years with a synthetic somatostatin analog ( SMS 201/995). The treatment of choice in cases in which the tumour was fully removable is surgical resection. This occurred rarely since approximately 80% of VIPomas are malignant and are operated late when local infiltration is already widespread; in addition, 50% of cases are already metastasised at diagnosis. In this case, due to the infiltration of the superior mesenteric artery by the primary tumour it was necessary to carry out a left pancreasectomy which included two-thirds of the neoplastic mass. This was justified by slow tumour growth and also facilitated control of diarrhea and ensured a greater efficacy of possible postoperative chemotherapy. The use of synthetic somatostatin analog ( SMS 201/995) enabled diarrhea to be satisfactorily controlled and is therefore specifically indicated for this type of tumour. NSE serum assay ( neuron specific enolase) allowed the evolution of disease to be monitored during follow-up.
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Authors | F Procacciante, P Picozzi, A Fantini, M Pacifici, A Di Nardo, G Ribotta, G Delle Fave, M Catani, S Ruggeri, F Romeo |
Journal | Minerva chirurgica
(Minerva Chir)
Vol. 47
Issue 3-4
Pg. 135-42
(Feb 1992)
ISSN: 0026-4733 [Print] Italy |
Vernacular Title | VIPoma: trattamento chirurgico. |
PMID | 1314346
(Publication Type: Case Reports, English Abstract, Journal Article)
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Chemical References |
- Phosphopyruvate Hydratase
|
Topics |
- Female
- Humans
- Liver Neoplasms
(secondary)
- Middle Aged
- Pancreatic Neoplasms
(enzymology, surgery)
- Phosphopyruvate Hydratase
(blood)
- Vipoma
(enzymology, secondary, surgery)
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