HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Immunoglobulin A-induced shift of Epstein-Barr virus tissue tropism.

Abstract
Increased immunoglobulin A (IgA) antibodies to the Epstein-Barr virus (EBV) appear months to years before the clinical onset of nasopharyngeal carcinoma and define populations at high risk for this EBV-associated epithelial cancer common in south China. In the human HT-29 epithelial cell line, polymeric IgA (pIgA) specific for EBV promoted infection of the otherwise refractory epithelial cells. When bound to pIgA, EBV entered epithelial cells through secretory component-mediated IgA transport but no longer infected B lymphocytes. Such an immune-induced shift in EBV tissue tropism provides a paradigm for endogenous spread of EBV in the immune host that predicts infectious sequelae of epithelium.
AuthorsJ W Sixbey, Q Y Yao
JournalScience (New York, N.Y.) (Science) Vol. 255 Issue 5051 Pg. 1578-80 (Mar 20 1992) ISSN: 0036-8075 [Print] UNITED STATES
PMID1312750 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Gene Products, env
  • Immunoglobulin A
  • Secretory Component
Topics
  • B-Lymphocytes (immunology, microbiology)
  • Base Sequence
  • Epithelium (microbiology)
  • Gene Products, env
  • Herpesvirus 4, Human (pathogenicity)
  • Humans
  • Immunoglobulin A (immunology)
  • In Vitro Techniques
  • Infectious Mononucleosis (immunology)
  • Lymphocyte Activation (immunology)
  • Molecular Sequence Data
  • Nasopharyngeal Neoplasms (immunology)
  • Secretory Component (physiology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: