Immunoglobulin A-induced shift of Epstein-Barr virus tissue tropism.

Increased immunoglobulin A (IgA) antibodies to the Epstein-Barr virus (EBV) appear months to years before the clinical onset of nasopharyngeal carcinoma and define populations at high risk for this EBV-associated epithelial cancer common in south China. In the human HT-29 epithelial cell line, polymeric IgA (pIgA) specific for EBV promoted infection of the otherwise refractory epithelial cells. When bound to pIgA, EBV entered epithelial cells through secretory component-mediated IgA transport but no longer infected B lymphocytes. Such an immune-induced shift in EBV tissue tropism provides a paradigm for endogenous spread of EBV in the immune host that predicts infectious sequelae of epithelium.
AuthorsJ W Sixbey, Q Y Yao
JournalScience (New York, N.Y.) (Science) Vol. 255 Issue 5051 Pg. 1578-80 (Mar 20 1992) ISSN: 0036-8075 [Print] UNITED STATES
PMID1312750 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Gene Products, env
  • Immunoglobulin A
  • Secretory Component
  • B-Lymphocytes (immunology, microbiology)
  • Base Sequence
  • Epithelium (microbiology)
  • Gene Products, env
  • Herpesvirus 4, Human (pathogenicity)
  • Humans
  • Immunoglobulin A (immunology)
  • In Vitro Techniques
  • Infectious Mononucleosis (immunology)
  • Lymphocyte Activation (immunology)
  • Molecular Sequence Data
  • Nasopharyngeal Neoplasms (immunology)
  • Secretory Component (physiology)

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