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Evaluation of colostral IgG1 absorption in newborn calves after treatment with alkalinizing agents.

Abstract
The effects of alkalinizing agents, administered prior to feeding colostrum, on blood-gas and acid-base values and on absorption of IgG1 were determined in 40 newborn Holstein calves. Two treatments, sodium bicarbonate (3 mEq/kg of body weight, IV) and doxapram HCl (2 mg/kg, IV), were evaluated, using a randomized complete-block experimental design. These treatments resulted in significant (P less than 0.01) alteration of blood-gas and acid-base values, generally in the direction of normal values for adult cattle. Significant least squares mean effects were detected for sodium bicarbonate treatment on blood pH (+ 0.04 units, P less than 0.01), PCO2 (+ 4.1 mm of Hg, P less than 0.01), and HCO3 concentration (+ 4.4 mEq/L, P less than 0.01). Significant least squares mean effects were detected for doxapram HCl treatment on blood pH (+ 0.06 pH units, P less than 0.01) and PCO2 (-5.2 mm of Hg, P less than 0.01). Absorption of colostral IgG1 was not affected by the treatments given or by the altered blood-gas and/or acid-base status.
AuthorsM W Ayers, T E Besser
JournalAmerican journal of veterinary research (Am J Vet Res) Vol. 53 Issue 1 Pg. 83-6 (Jan 1992) ISSN: 0002-9645 [Print] United States
PMID1311539 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Bicarbonates
  • Immunoglobulin G
  • Carbon Dioxide
  • Sodium Bicarbonate
  • Doxapram
  • Sodium
Topics
  • Absorption
  • Acid-Base Equilibrium
  • Animals
  • Animals, Newborn (metabolism)
  • Bicarbonates (blood, pharmacology)
  • Blood Gas Analysis
  • Carbon Dioxide (blood)
  • Cattle (metabolism)
  • Colostrum (immunology)
  • Doxapram (pharmacology)
  • Immunoglobulin G (metabolism)
  • Least-Squares Analysis
  • Random Allocation
  • Sodium (blood, pharmacology)
  • Sodium Bicarbonate

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