Abstract |
The effects of alkalinizing agents, administered prior to feeding colostrum, on blood-gas and acid-base values and on absorption of IgG1 were determined in 40 newborn Holstein calves. Two treatments, sodium bicarbonate (3 mEq/kg of body weight, IV) and doxapram HCl (2 mg/kg, IV), were evaluated, using a randomized complete-block experimental design. These treatments resulted in significant (P less than 0.01) alteration of blood-gas and acid-base values, generally in the direction of normal values for adult cattle. Significant least squares mean effects were detected for sodium bicarbonate treatment on blood pH (+ 0.04 units, P less than 0.01), PCO2 (+ 4.1 mm of Hg, P less than 0.01), and HCO3 concentration (+ 4.4 mEq/L, P less than 0.01). Significant least squares mean effects were detected for doxapram HCl treatment on blood pH (+ 0.06 pH units, P less than 0.01) and PCO2 (-5.2 mm of Hg, P less than 0.01). Absorption of colostral IgG1 was not affected by the treatments given or by the altered blood-gas and/or acid-base status.
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Authors | M W Ayers, T E Besser |
Journal | American journal of veterinary research
(Am J Vet Res)
Vol. 53
Issue 1
Pg. 83-6
(Jan 1992)
ISSN: 0002-9645 [Print] United States |
PMID | 1311539
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Bicarbonates
- Immunoglobulin G
- Carbon Dioxide
- Sodium Bicarbonate
- Doxapram
- Sodium
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Topics |
- Absorption
- Acid-Base Equilibrium
- Animals
- Animals, Newborn
(metabolism)
- Bicarbonates
(blood, pharmacology)
- Blood Gas Analysis
- Carbon Dioxide
(blood)
- Cattle
(metabolism)
- Colostrum
(immunology)
- Doxapram
(pharmacology)
- Immunoglobulin G
(metabolism)
- Least-Squares Analysis
- Random Allocation
- Sodium
(blood, pharmacology)
- Sodium Bicarbonate
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