Anemia in experimental visceral leishmaniasis in hamsters.

Abstract

Experimental infection of hamsters with Leishmania donovani caused visceral leishmaniasis in which hematological changes occurred. The infected hamsters were anemic and reticulocyte counts were high. No significant change in the serum erythropoietin level was noted. Red cell membrane Na(+)-K(+)-ATPase and acetylcholinesterase activities increased. Osmotic fragility of the erythrocytes from infected animals increased. The level of 2,3-diphosphoglycerate of the red cells increased with the degree of anemia.

• Authors: T Biswas, M Chakraborty, K Naskar, D K Ghosh, J Ghosal
• Journal: The Journal of parasitology (J Parasitol) Vol. 78 Issue 1 Pg. 140-2 (Feb 1992) ISSN: 0022-3395 [Print] United States
• PMID: 1310731 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Diphosphoglyceric Acids
• Hemoglobins
• Erythropoietin
• 2,3-Diphosphoglycerate
• Acetylcholinesterase
• Sodium-Potassium-Exchanging ATPase

Topics

• 2,3-Diphosphoglycerate
• Acetylcholinesterase (blood)
• Anemia (blood, etiology)
• Animals
• Cricetinae
• Diphosphoglyceric Acids (blood)
• Erythrocyte Membrane (enzymology)
• Erythrocytes (chemistry)
• Erythropoietin (blood)
• Hemoglobins (analysis)
• Leishmaniasis, Visceral (blood, complications)
• Osmotic Fragility
• Sodium-Potassium-Exchanging ATPase (blood)