Efficacy and safety of nedocromil sodium ophthalmic solution in the treatment of seasonal allergic conjunctivitis.

Abstract

To assess the efficacy and safety of twice-daily administration of nedocromil sodium 2% ophthalmic solution, we performed a multicenter study involving 140 patients with seasonal allergic conjunctivitis. Subjects had a history of seasonal allergic conjunctivitis and positive results of a skin test to ragweed. The trial coincided with the peak ragweed pollen season at five treatment centers. Patients treated with nedocromil sodium had improvements in symptoms with statistically significant reductions recorded for eye itching (P less than or equal to .04), conjunctival injection (P less than or equal to .001), and overall disease severity (P less than or equal to .001) as compared to the placebo-treated group. Adverse events were minor and transient. We concluded that nedocromil sodium 2% ophthalmic solution administered twice daily is effective in relieving major symptoms associated with seasonal allergic conjunctivitis.

• Authors: M Blumenthal, T Casale, R Dockhorn, I Jarmoszuk, H Kaiser, R Smith, H J Zeitz
• Journal: American journal of ophthalmology (Am J Ophthalmol) Vol. 113 Issue 1 Pg. 56-63 (Jan 15 1992) ISSN: 0002-9394 [Print] United States
• PMID: 1309410 (Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Ophthalmic Solutions
• Quinolones
• Nedocromil

Topics

• Adolescent
• Adult
• Anti-Inflammatory Agents, Non-Steroidal (administration & dosage, adverse effects)
• Child
• Conjunctivitis, Allergic (drug therapy)
• Drug Administration Schedule
• Drug Evaluation
• Female
• Humans
• Male
• Middle Aged
• Nedocromil
• Ophthalmic Solutions
• Quinolones (administration & dosage, adverse effects)