A histological study of infectious canine hepatitis by means of fluorescent antibody.

Abstract	A study of experimental infectious canine hepatitis in dogs by means of specific fluorescent antibody indicates that the intranuclear inclusions of this disease contain high concentrations of viral antigen. The increase in virus in the nuclei, as indicated by the accumulation of specific antigenic material, begins on the nuclear membrane and spreads from there to the interior of the nucleus, with the gradual formation of larger granules. Subsequently there appear the homogeneous inclusion bodies characteristic of this infection.
Authors	D L COFFIN, A H COONS, V J CABASSO
Journal	The Journal of experimental medicine (J Exp Med) Vol. 98 Issue 1 Pg. 13-20 (Jul 1953) ISSN: 0022-1007 [Print] United States
PMID	13069646 (Publication Type: Journal Article)
Chemical References	Antibodies Antigens Antigens, Viral
Topics	Animals Antibodies Antigens Antigens, Viral Cell Nucleus Dogs Fluorescent Antibody Technique Hepatitis A Hepatitis, Infectious Canine

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