[The inhibiting effect of phytoadaptogenic preparations from bioginseng, Eleutherococcus senticosus and Rhaponticum carthamoides on the development of nervous system tumors in rats induced by N-nitrosoethylurea].

Abstract

The study was concerned with the inhibitory effect of officinal preparations of phytoadaptogenic drugs such as bioginseng and Eleutherococcus senticosus and Rhaponticum carthamoides root extracts on the carcinogenesis induced by transplacental administration of N-nitrosoethylurea. The phytodrugs were given orally over a year. The administration of the drugs was followed by longer survival of the rats and lower occurrence and/or multiplicity of tumors (mainly those of the central nervous system). The drugs were placed in the order of decreasing anticarcinogenic activity as follows: bioginseng, Rhaponticum carthamoides extract and Eleutherococcus senticosus extract.

• Authors: V G Bespalov, V A Aleksandrov, K V Iaremenko, V V Davydov, N L Lazareva, A Iu Limarenko, L I Slepian, A S Petrov, D N Troian
• Journal: Voprosy onkologii (Vopr Onkol) Vol. 38 Issue 9 Pg. 1073-80 ( 1992) ISSN: 0507-3758 [Print] Russia (Federation)
• Vernacular Title: Tormoziashchiĭ éffekt fitoadaptogennykh preparatov biozhen'shenia, éleuterokokka koliuchego i levzei saflovidnoĭ na razvitie opukholeĭ nervnoĭ sistemy u krys, indutsirovannykh N-nitrozoétilmochevinoĭ.
• PMID: 1300820 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Antineoplastic Agents, Phytogenic
• Plant Extracts
• Ethylnitrosourea

Topics

• Animals
• Antineoplastic Agents, Phytogenic (therapeutic use)
• Chi-Square Distribution
• Drug Screening Assays, Antitumor
• Ethylnitrosourea
• Female
• Kidney Neoplasms (chemically induced, epidemiology, prevention & control)
• Nervous System Neoplasms (chemically induced, epidemiology, prevention & control)
• Panax
• Phytotherapy
• Plant Extracts (administration & dosage)
• Plants, Medicinal
• Pregnancy
• Prenatal Exposure Delayed Effects
• Rats
• Time Factors