[Studies of the lymphatic system in mice infected with Trichinella pseudospiralis as well as infected and stimulated by Phytohaemagglutin (PHA-P)].

Abstract

Mice CFW were infected per os with Trichinella pseudospiralis (150 larvae/mice). The mice were divided in two groups: nonstimulated and stimulated intraperitoneally with PHA-P at dose 10 mg/kg body weight. The animals were killed 7, 14, 21, 28, 42, 56, 70 and 150 day post infection (d.p.i.). Spleen et mesenteric lymph nodes were examined histopathologically (Hematoxylin-Eosin) and histochemically (nonspecific esterase reaction) for differentiation of T lymphocytes. The obtained results reveal that T. pseudospiralis infection caused weak mobilisation of mouse lymphatic system lasting only to 70 day of experiment. In the lymphatic organs of infected mice small number of T lymphocytes were observed mostly between 28 and 56 d.p.i. The intraperitoneally stimulation with PHA-P give rise to caused only little mobilisation of lymphatic tissue and small increase of T lymphocytes number. The obtained results were compared with analogic earlier experiments with T. spiralis infection.

• Authors: Z Michalska
• Journal: Wiadomosci parazytologiczne (Wiad Parazytol) Vol. 38 Issue 3-4 Pg. 103-8 ( 1992) ISSN: 0043-5163 [Print] Poland
• Vernacular Title: Badania układu limfatycznego myszy zarazonych T. pseudospiralis oraz zarazonych i stymulowanych fitohemaglutynina (PHA-P).
• PMID: 1299055 (Publication Type: English Abstract, Journal Article)

Chemical References

• Phytohemagglutinins

Topics

• Animals
• Leukocyte Count
• Lymph Nodes (immunology, pathology)
• Male
• Mice
• Phytohemagglutinins (pharmacology)
• Spleen (immunology, pathology)
• T-Lymphocytes (immunology)
• Trichinellosis (immunology)