HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Pharmacological treatment of intermittent claudication: double blind controlled study of Sulodexide vs placebo.

Abstract
A double blind placebo controlled randomized study was used to assess the clinical variations caused by Sulodexide treatment (100 mg/die) vs placebo in 30 patients with a mean age of 50.3 years suffering from peripheral arterial obstructive disease of the lower limbs (II stage). The general tolerance of the therapy was monitored over the medium-term. There were marked changes in the clinical signs and symptoms in the Sulodexide group, which showed a gradual constant improvement, while they were stationary in the placebo group. Confirmation of the marked improvement in the Sulodexide group was provided by the Winsor index which showed a significant increase in these patients while only a minimum variation was observed in the placebo group. The positive antithrombotic action of the active treatment led to an increase in the blood supply in previously ischemic regions, without creating haemorrhagic risks or disturbing the haemostatic balance. The absence of adverse reactions and good systemic tolerance is also noteworthy.
AuthorsG Catania, T Salanitri
JournalRivista europea per le scienze mediche e farmacologiche = European review for medical and pharmacological sciences = Revue europeenne pour les sciences medicales et pharmacologiques (Riv Eur Sci Med Farmacol) 1992 May-Jun Vol. 14 Issue 3 Pg. 149-57 ISSN: 0392-291X [Print] Italy
PMID1298968 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
Chemical References
  • Glycosaminoglycans
  • glucuronyl glucosamine glycan sulfate
Topics
  • Adult
  • Aged
  • Double-Blind Method
  • Female
  • Glycosaminoglycans (therapeutic use)
  • Humans
  • Intermittent Claudication (drug therapy)
  • Male
  • Middle Aged

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: