Abstract | BACKGROUND: AIMS: To evaluate VEGF serum levels in HHT patients as compared to normal subjects. MATERIALS AND METHODS: 32 HHT patients (age 47.7 +/- 16.7 years) and a control group of 37 healthy subjects (age 48.2 +/- 15.5 years) were entered in the study. Each patient underwent serum VEGF dosage using a commercial ELISA specific for the human molecule. RESULTS: The serum level of VEGF in HHT patients was 196.3 +/- 103.2 pg/ml, while it was 152.0 +/- 84.1 pg/ml in the control group. Statistical analysis showed that serum VEGF was significantly higher in HHT patients than in the controls (p < 0.031). CONCLUSIONS: According to a study performed in a murine model, persistence of the activation phase of angiogenesis might be responsible for an increased production of several angiogenic factors, in particular VEGF, in HHT. Our work is the first to suggest an increased expression of VEGF in the serum of subjects with HHT in agreement with the stimulation of VEGF synthesis proposed in the murine model.
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Authors | Anna Cirulli, Arcangelo Liso, Francesco D'Ovidio, Anna Mestice, Giovanna Pasculli, Mauro Gallitelli, Rita Rizzi, Giorgina Specchia, Carlo Sabbà |
Journal | Acta haematologica
(Acta Haematol)
Vol. 110
Issue 1
Pg. 29-32
( 2003)
ISSN: 0001-5792 [Print] Switzerland |
PMID | 12975554
(Publication Type: Journal Article)
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Copyright | Copyright 2003 S. Karger AG, Basel |
Chemical References |
- Biomarkers
- Endothelial Growth Factors
- Intercellular Signaling Peptides and Proteins
- Lymphokines
- Vascular Endothelial Growth Factor A
- Vascular Endothelial Growth Factors
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Topics |
- Adult
- Biomarkers
- Endothelial Growth Factors
(blood)
- Epistaxis
(blood)
- Humans
- Intercellular Signaling Peptides and Proteins
(blood)
- Lymphokines
(blood)
- Middle Aged
- Recurrence
- Telangiectasia, Hereditary Hemorrhagic
(blood, diagnosis)
- Vascular Endothelial Growth Factor A
- Vascular Endothelial Growth Factors
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