Abstract | OBJECTIVE: RESULTS: Our results revealed a significant statistical correlation between the intensity of inflammatory infiltrate and the percentage of mononuclear cells positive for IL-4. Moreover, we observed a statistically significant correlation between the frequency of cells expressing IL-6 and LT-alpha. CONCLUSION: These data suggest that the predominance of a helper T cell subtype 2 response in dental granulomas is correlated with the exacerbation of the inflammatory reaction and its evolution. Moreover, a correlation between the frequency of IL-6-positive and LT-alpha-positive cells suggests that the synergistic activities of these 2 cytokines may be involved in the pathogenesis of this inflammatory condition.
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Authors | Alessandra Rosa de Sá, Flávio Juliano Garcia Santos Pimenta, Walderez Ornelas Dutra, Ricardo Santiago Gomez |
Journal | Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
(Oral Surg Oral Med Oral Pathol Oral Radiol Endod)
Vol. 96
Issue 3
Pg. 356-60
(Sep 2003)
ISSN: 1079-2104 [Print] United States |
PMID | 12973294
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Interleukin-6
- Lymphotoxin-alpha
- Interleukin-4
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Topics |
- Adult
- Humans
- Immunoenzyme Techniques
- Interleukin-4
(analysis)
- Interleukin-6
(analysis)
- Leukocyte Count
- Leukocytes, Mononuclear
(pathology)
- Lymphocyte Count
- Lymphotoxin-alpha
(analysis)
- Middle Aged
- Periapical Granuloma
(pathology)
- Statistics, Nonparametric
- T-Lymphocytes, Helper-Inducer
(pathology)
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