Monoclonal antibody to parathyroid hormone-related protein induces differentiation and apoptosis of chondrosarcoma cells.

Abstract	We investigated the effects of treatment with anti-parathyroid hormone-related protein (1-34) monoclonal murine antibody (anti-PTHrP MoAb) on apoptosis and the differentiation of chondrosarcoma HTB-94 cells. Treatment with anti-PTHrP MoAb accelerated apoptosis of HTB-94 cells in a dose-dependent manner, and anti-PTHrP MoAb also promoted the chondrogenic differentiation of HTB-94 cells. The induction of apoptosis by anti-PTHrP MoAb via imbalance of Bcl-2/Bax ratio and activation of caspase-3 may provide a mechanistic explanation for its potential antitumor effects. Our results suggest the possibility that anti-PTHrP MoAb may be beneficial as a new treatment for chondrosarcoma.
Authors	Takahiro Miyaji, Takanobu Nakase, Eturo Onuma, Koh Sato, Akira Myoui, Tetsuya Tomita, Susumu Joyama, Kenta Ariga, Jun Hashimoto, Takafumi Ueda, Hideki Yoshikawa
Journal	Cancer letters (Cancer Lett) Vol. 199 Issue 2 Pg. 147-55 (Sep 25 2003) ISSN: 0304-3835 [Print] Ireland
PMID	12969787 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Antibodies, Monoclonal BAX protein, human Collagen Type II Collagen Type X DNA Primers Parathyroid Hormone-Related Protein Peptide Fragments Proto-Oncogene Proteins Proto-Oncogene Proteins c-bcl-2 bcl-2-Associated X Protein CASP3 protein, human Caspase 3 Caspases
Topics	Antibodies, Monoclonal (pharmacology) Apoptosis (drug effects) Bone Neoplasms (immunology, metabolism, pathology) Caspase 3 Caspases (metabolism) Cell Differentiation (drug effects) Cell Division (drug effects) Chondrosarcoma (immunology, metabolism, pathology) Collagen Type II (genetics, metabolism) Collagen Type X (genetics, metabolism) DNA Primers (chemistry) Humans Immunoenzyme Techniques Parathyroid Hormone-Related Protein (immunology) Peptide Fragments (immunology) Proto-Oncogene Proteins (genetics, metabolism) Proto-Oncogene Proteins c-bcl-2 (genetics, metabolism) Reverse Transcriptase Polymerase Chain Reaction Tumor Cells, Cultured bcl-2-Associated X Protein

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