Protective effects of glycyrrhizin on gentamicin-induced acute renal failure in rats.

Abstract	The aim of this study was to investigate the effects of glycyrrhizin (200 mg/kg/day) on renal function in association with the regulation of aquaporin 2 water channel in rats with gentamicin (100 mg/kg/day)-induced acute renal failure. Polyuria in rats with gentamicin-induced acute renal failure was associated with down-regulation of renal aquaporin 2 in the inner and outer renal medulla, and cortex. Glycyrrhizin administration restored the expression of aquaporin 2 with paralleled changes in urine output. Changes in renal functional parameters, such as creatinine clearance, urinary osmolality, and solute-free reabsorption, accompanying acute renal failure were also partially restored after administration of glycyrrhizin. Histological changes in rats with gentamicin-induced acute renal failure were also abrogated by glycyrrhizin treatment. The above results suggest that glycyrrhizin treatment could ameliorate renal defects in rats with acute renal failure induced by gentamicin.
Authors	Eun-Jin Sohn, Dae-Gill Kang, Ho-Sub Lee
Journal	Pharmacology & toxicology (Pharmacol Toxicol) Vol. 93 Issue 3 Pg. 116-22 (Sep 2003) ISSN: 0901-9928 [Print] Denmark
PMID	12969435 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Anti-Bacterial Agents Aqp2 protein, rat Aquaporin 2 Aquaporin 6 Aquaporins Gentamicins Protective Agents Glycyrrhizic Acid
Topics	Acute Kidney Injury (chemically induced, prevention & control) Administration, Oral Animals Anti-Bacterial Agents (adverse effects) Aquaporin 2 Aquaporin 6 Aquaporins (biosynthesis) Blotting, Western Down-Regulation Gentamicins (adverse effects) Glycyrrhizic Acid (administration & dosage, pharmacology, therapeutic use) Kidney (drug effects, pathology, physiopathology) Kidney Function Tests Male Phytotherapy Protective Agents (administration & dosage, pharmacology, therapeutic use) Rats Rats, Sprague-Dawley

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