Abstract | OBJECTIVE: This study was performed to elucidate the pharmacokinetic profiles of antimycobacterial regimens for peritoneal dialysis patients. PATIENTS: METHODS: After administering a conventional oral dose of antituberculosis medications, we measured plasma and peritoneal fluid concentrations of isoniazid by fluorometry, and rifampin and pyrazinamide by high performance liquid chromatography. The assay data were subjected to pharmacokinetic analysis. RESULTS: Average peak plasma concentrations of isoniazid, rifampin, and pyrazinamide were 3.3 mg/L, 6.5 mg/L, and 30.9 mg/L, respectively, all of which much exceed the minimum inhibitory concentration (MIC) for Mycobacterium tuberculosis. Peritoneal fluid concentrations of isoniazid and pyrazinamide were maintained well above the MICs for M. tuberculosis; however, peritoneal fluid concentration of rifampin was below the therapeutic range most of the time. CONCLUSION:
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Authors | Curie Ahn, Kook-Hwan Oh, Kiwon Kim, Kyung Yi Lee, Jung Geon Lee, Myung Don Oh, Yonsu Kim, Jin Suk Han, Suhnggwon Kim, Jung Sang Lee, In-Jin Jang, Sang-Goo Shin |
Journal | Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis
(Perit Dial Int)
2003 Jul-Aug
Vol. 23
Issue 4
Pg. 362-7
ISSN: 0896-8608 [Print] United States |
PMID | 12968844
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antitubercular Agents
- Pyrazinamide
- Isoniazid
- Rifampin
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Topics |
- Adult
- Antitubercular Agents
(analysis, blood, pharmacokinetics)
- Ascitic Fluid
(chemistry)
- Female
- Humans
- Isoniazid
(analysis, blood, pharmacokinetics)
- Male
- Middle Aged
- Peritoneal Dialysis, Continuous Ambulatory
(methods)
- Pyrazinamide
(analysis, blood, pharmacokinetics)
- Rifampin
(analysis, blood, pharmacokinetics)
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