Abstract | BACKGROUND: OBJECTIVE: METHODS: RESULTS: Preinjection visual acuity ranged from 20/50 to 20/400. An extensive inflammatory response developed 1 to 2 days after injection in all 7 eyes. Five eyes had previously undergone vitrectomy. Four eyes had a layered hypopyon. All 7 eyes had an anterior chamber cellular reaction and vitritis. Visual acuity ranged from 20/400 to hand movements. The first 6 patients were treated for presumed endophthalmitis with vitreous cultures and intravitreal injections of antibiotics. All 6 cultures were negative for any organisms, and the eyes resolved their inflammatory response, with recovery to preinjection visual acuity or better. The seventh patient was treated with topical prednisolone without antibiotic therapy, and the inflammation resolved, with resolution of the macular edema seen before the intravitreal triamcinolone injection. CONCLUSION: It may be appropriate to closely observe noninfectious, toxic endophthalmitis in patients treated with intravitreal triamcinolone before assuming it to be infectious, especially in the absence of eye pain.
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Authors | Daniel B Roth, Janet Chieh, Marc J Spirn, Stuart N Green, David L Yarian, Nauman A Chaudhry |
Journal | Archives of ophthalmology (Chicago, Ill. : 1960)
(Arch Ophthalmol)
Vol. 121
Issue 9
Pg. 1279-82
(Sep 2003)
ISSN: 0003-9950 [Print] United States |
PMID | 12963610
(Publication Type: Journal Article)
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Chemical References |
- Glucocorticoids
- Triamcinolone Acetonide
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Diabetic Retinopathy
(complications)
- Endophthalmitis
(chemically induced)
- Female
- Glucocorticoids
(adverse effects)
- Humans
- Injections
- Macular Edema
(drug therapy, etiology)
- Male
- Middle Aged
- Pseudophakia
(complications)
- Retinal Vein Occlusion
(complications)
- Triamcinolone Acetonide
(adverse effects)
- Visual Acuity
- Vitrectomy
- Vitreous Body
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