Abstract |
The anti-metastatic effect of 4-[3,5-bis(trimethylsilyl)benzamido] benzoic acid (TAC-101) was investigated using our established intrahepatic metastasis model. Orthotopic implantation of a fragment of CBO140C12 hepatoma into the liver resulted in the formation of a solitary tumor nodule and its intrahepatic metastasis. Daily oral administration of TAC-101 at a dose of 8 mg/kg resulted in a significant inhibition of intrahepatic metastasis, but did not affect the growth of the tumor at the implanted site. The down-regulation of transcriptional anti- activator protein-1 (AP-1) activity by TAC-101 paralleled the inhibition of cell invasion and migration through the repression of expression of the mRNAs for urokinase-type plasminogen activator ( u-PA) and its receptor (u-PAR). These findings suggest that TAC-101 may improve therapeutic efficacy for liver cancer patients to prevent intrahepatic metastasis.
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Authors | Soo Jin Lee, Yasukata Ohashi, Hiroaki Sakurai, Ikuo Saiki |
Journal | Cancer letters
(Cancer Lett)
Vol. 198
Issue 2
Pg. 169-77
(Aug 20 2003)
ISSN: 0304-3835 [Print] Ireland |
PMID | 12957355
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anticarcinogenic Agents
- Benzoates
- DNA Primers
- Drug Implants
- TAC 101
- Transcription Factor AP-1
- Trimethylsilyl Compounds
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Topics |
- Animals
- Anticarcinogenic Agents
(administration & dosage, pharmacology)
- Base Sequence
- Benzoates
(administration & dosage, pharmacology)
- Carcinoma, Hepatocellular
(chemically induced, pathology, prevention & control)
- Cell Division
(drug effects)
- Cell Movement
(drug effects)
- DNA Primers
- Disease Models, Animal
- Drug Implants
- Liver Neoplasms
(chemically induced, pathology, prevention & control, secondary)
- Mice
- Mice, Inbred Strains
- Neoplasm Invasiveness
- Neoplasm Metastasis
(prevention & control)
- Reverse Transcriptase Polymerase Chain Reaction
- Transcription Factor AP-1
(antagonists & inhibitors, drug effects, metabolism)
- Trimethylsilyl Compounds
(administration & dosage, pharmacology)
- Tumor Cells, Cultured
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