Abstract | OBJECTIVE: DESIGN: SETTING: University research laboratory. MEASUREMENTS AND RESULTS:
Mesenteric ischemia/reperfusion significantly increased ileal mucosal permeability to the hydrophilic macromolecule, fluorescein isothiocyanate dextran (molecular mass 4,000 Da). Whereas the lowest dose of ethyl pyruvate evaluated (17 mg/kg) had no effect on gut mucosal permeability, the two highest doses tested (50 and 150 mg/kg) significantly ameliorated the development of ischemia/reperfusion-induced mucosal hyperpermeability to about the same extent. The two highest doses of ethyl pyruvate also significantly ameliorated deficits in ileal serosal and mucosal and hepatic surface microvascular perfusion induced by mesenteric ischemia/reperfusion. Ethyl pyruvate inhibited post- ischemia/reperfusion hepatic NF-kappaB activation and TNF mRNA expression in a dose-dependent fashion. CONCLUSION:
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Authors | Takashi Uchiyama, Russell L Delude, Mitchell P Fink |
Journal | Intensive care medicine
(Intensive Care Med)
Vol. 29
Issue 11
Pg. 2050-8
(Nov 2003)
ISSN: 0342-4642 [Print] United States |
PMID | 12955182
(Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Free Radical Scavengers
- NF-kappa B
- Pyruvates
- Tumor Necrosis Factor-alpha
- ethyl pyruvate
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Topics |
- Analysis of Variance
- Animals
- Blood Pressure
(drug effects)
- Capillary Permeability
(drug effects)
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Drug Evaluation, Preclinical
- Free Radical Scavengers
(pharmacology, therapeutic use)
- Ileum
(blood supply, drug effects)
- Intestinal Mucosa
(blood supply, drug effects)
- Ischemia
(drug therapy, immunology, metabolism)
- Laser-Doppler Flowmetry
- Liver
(chemistry, drug effects)
- Male
- Mesenteric Vascular Occlusion
- Mesentery
(blood supply)
- Mice
- Mice, Inbred C57BL
- NF-kappa B
(analysis, drug effects)
- Pyruvates
(pharmacology, therapeutic use)
- Reperfusion Injury
(drug therapy, immunology, metabolism)
- Time Factors
- Tumor Necrosis Factor-alpha
(analysis, drug effects)
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