Disseminated paracoccidioidomycosis: correlation between clinical and in vitro resistance to ketoconazole and trimethoprim sulphamethoxazole.

Abstract

The present study relates to a case of subacute multifocal paracoccidioidomycosis where the upper intestinal tract is involved. The involvement of the upper digestive tract is uncommon. The recommended therapeutic treatment plans and the difficulty in the treatment of paracoccidioidomycosis are discussed in association with susceptibility tests to antifungal drugs in vitro. This is the first report available in the literature showing, in parallel, clinical and in vitro resistance to ketoconazole and trimethoprim sulphamethoxazole, studied during the course of the disease.

• Authors: Rosane Christine Hahn, Yvelise Teresinha Morato Conceição, Niriana Lara Santos, Jussara Fialho Ferreira, Júnia Soares Hamdan
• Journal: Mycoses (Mycoses) Vol. 46 Issue 8 Pg. 342-7 (Sep 2003) ISSN: 0933-7407 [Print] Germany
• PMID: 12950907 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Infective Agents
• Trimethoprim, Sulfamethoxazole Drug Combination
• Ketoconazole

Topics

• Adult
• Anti-Infective Agents (pharmacology, therapeutic use)
• Drug Resistance, Fungal
• Humans
• Ketoconazole (pharmacology, therapeutic use)
• Male
• Microbial Sensitivity Tests
• Paracoccidioides (drug effects)
• Paracoccidioidomycosis (drug therapy, microbiology)
• Trimethoprim, Sulfamethoxazole Drug Combination (pharmacology, therapeutic use)