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Laminin, hyaluronan, tenascin-C and type VI collagen levels in sera from patients with malignant melanoma.

Abstract
In this study, hyaluronan, laminin-1, tenascin-C and type VI collagen were measured in the sera of patients with stage I/II and stage IV melanoma. A significant increase in the serum levels of all four extracellular matrix proteins was found in patients with stage IV melanoma compared to healthy donors. Type VI collagen and hyaluronan serum levels were also significantly increased in stage I/II melanoma. Increased expression of the four matrix proteins was also demonstrated in melanoma cell lines using reverse transcriptase- polmerase chain reaction (RT-PCR) and enzyme-linked immunosorbent assay (ELISA). We suggest that tenascin-C, hyaluronan, laminin-1 and type VI collagen are involved in melanoma development and extracellular matrix remodelling during melanoma progression. This finding will be of interest in the development of serum markers for progression of malignant melanoma.
AuthorsE R Burchardt, R Hein, A K Bosserhoff
JournalClinical and experimental dermatology (Clin Exp Dermatol) Vol. 28 Issue 5 Pg. 515-20 (Sep 2003) ISSN: 0307-6938 [Print] England
PMID12950343 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Collagen Type VI
  • Laminin
  • Tenascin
  • laminin 1
  • Hyaluronic Acid
Topics
  • Cell Line
  • Collagen Type VI (blood)
  • Female
  • Humans
  • Hyaluronic Acid (blood)
  • Immunoassay (methods)
  • Laminin (blood)
  • Male
  • Melanoma (blood)
  • Middle Aged
  • Reverse Transcriptase Polymerase Chain Reaction (methods)
  • Skin Neoplasms (blood)
  • Tenascin (blood)

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