Ultralow doses of various drugs in chemotherapy of experimental tumors.

Abstract

Antitumor activity of ultralow doses of cytostatic lonidamine and effects of various biological preparations in ultralow doses (chemosensitizer, immunomodulator, and antioxidant) on the efficiency of adriamycin and cisplatin were studied in animals with transplanted tumors. High efficiency of this method was demonstrated. Nitrotriazole chemosensitizer in ultralow doses increased the sensitivity of leukemia P388/rn substrain with multiple drug resistance phenotype to mitomycin C during combination therapy.

• Authors: N P Konovalova
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 135 Suppl 7 Pg. 45-7 (Jan 2003) ISSN: 1573-8221 [Electronic] United States
• PMID: 12949646 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Indazoles
• Triazoles
• AK 2123
• Mitomycin
• Doxorubicin
• Cisplatin
• lonidamine

Topics

• Animals
• Antineoplastic Agents (pharmacology, therapeutic use)
• Antineoplastic Combined Chemotherapy Protocols
• Cisplatin (therapeutic use)
• Dose-Response Relationship, Drug
• Doxorubicin (therapeutic use)
• Drug Resistance, Multiple (drug effects)
• Drug Resistance, Neoplasm (drug effects)
• Indazoles (therapeutic use)
• Leukemia P388 (drug therapy)
• Lung Neoplasms (drug therapy)
• Melanoma (drug therapy)
• Mice
• Mitomycin (therapeutic use)
• Neoplasm Metastasis (drug therapy)
• Neoplasms, Experimental (drug therapy)
• Triazoles (therapeutic use)
• Xenograft Model Antitumor Assays