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HLA class II antibodies in the treatment of hematologic malignancies.

Abstract
Promising results have suggested human leukocyte antigen (HLA) class II as potential target for antibody-based lymphoma therapy. Thus, antibodies against HLA class II induced apoptosis in vitro, as well as complement-dependent cytotoxicity (CDC) and effector cell-mediated cytotoxicity (ADCC). Furthermore, animal models demonstrated strong antitumor effects in vivo. Importantly, early clinical studies with antibodies Lym-1 or Hu1D10, both against HLA-DR variants, suggested therapeutic potential. However, the increased risk of serious toxicity may require an improved understanding of the clinically relevant mechanisms of action of HLA class II-directed antibodies, which may then allow generation of optimized antibody constructs to achieve optimal therapeutic efficacy.
AuthorsMichael Dechant, Joerg Bruenke, Thomas Valerius
JournalSeminars in oncology (Semin Oncol) Vol. 30 Issue 4 Pg. 465-75 (Aug 2003) ISSN: 0093-7754 [Print] United States
PMID12939715 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Antibodies, Monoclonal
  • Antineoplastic Agents
  • HLA-DR Antigens
  • Histocompatibility Antigens Class II
Topics
  • Antibodies, Monoclonal (therapeutic use)
  • Antibody-Dependent Cell Cytotoxicity (immunology)
  • Antineoplastic Agents (therapeutic use)
  • Apoptosis (immunology)
  • Cytotoxicity, Immunologic (immunology)
  • HLA-DR Antigens (immunology)
  • Hematologic Neoplasms (therapy)
  • Histocompatibility Antigens Class II (immunology)
  • Humans

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