Abstract | BACKGROUND:
Breast cancer is the most frequent type of tumor in women. The main cause of breast cancer remains unknown. Extensive studies have shown that endogenous steroid hormones, especially estrogens, are important in the development and the progression of breast cancer, and the carcinogenesis of estrogens is related to their major oxidative metabolites, 16alpha-hydroxyestrogens and 4-hydroxyestrogens. CYP3A plays a major role in the 4- and 16alpha-hydroxylation of estrogens. Furthermore, CYP3A is present in human mammary epithelial cells and expressed higher and more frequently in malignant breast cells than in the adjacent normal breast tissue. Hence, it will be significant to perform more work to determine the association between CYP3A activity and breast cancer susceptibility. AIMS: METHODS: One hundred and twenty-nine Chinese Han female breast tumor patients and 121 healthy unrelated female volunteers were enrolled in the current study. After an overnight fast, each subject was administered a single oral dose (7.5 mg) of midazolam. Blood samples (5 ml) were drawn at 1 h after the drug administration. The concentration of parent MDZ and its major metabolite 1-OH-MDZ was measured in all the plasma samples using high-performance liquid chromatography. RESULTS: CONCLUSIONS:
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Authors | Ping Huang, Bing Zhu, Lian-Sheng Wang, Dong-Sheng Ouyang, Song-Lin Huang, Xiao-Ping Chen, Hong-Hao Zhou |
Journal | European journal of clinical pharmacology
(Eur J Clin Pharmacol)
Vol. 59
Issue 5-6
Pg. 471-6
(Sep 2003)
ISSN: 0031-6970 [Print] Germany |
PMID | 12937874
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Receptors, Estrogen
- Receptors, Progesterone
- 1-hydroxymethylmidazolam
- Aryl Hydrocarbon Hydroxylases
- Cytochrome P-450 CYP3A
- Oxidoreductases, N-Demethylating
- Midazolam
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Topics |
- Aryl Hydrocarbon Hydroxylases
(genetics, metabolism)
- Asian People
- Breast Neoplasms
(ethnology, metabolism, pathology)
- China
- Cytochrome P-450 CYP3A
- Disease Susceptibility
- Female
- Humans
- Lymphatic Metastasis
- Midazolam
(analogs & derivatives, blood, metabolism)
- Oxidoreductases, N-Demethylating
(genetics, metabolism)
- Receptors, Estrogen
(metabolism)
- Receptors, Progesterone
(metabolism)
- Risk Factors
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