Safety and immunogenicity of a diphtheria, tetanus, and acellular pertussis-inactivated poliovirus vaccine/Haemophilus influenzae type B combination vaccine administered to Taiwanese infants at 2, 4, and 6 months of age.

Abstract

BACKGROUND:

Combined vaccines are urgently needed to ensure compliance with the increasing number of recommended vaccines for children. We evaluated the safety and antibody response to a diphtheria, tetanus, and acellular pertussis-inactivated poliovirus vaccine/Haemophilus influenzae type b (DTaP-IPV/Hib) combination vaccine administrated to infants at 2, 4, and 6 months of age.

METHODS:

Sixty healthy infants between 6 and 12 weeks of age were enrolled. One group of vaccines received the DTaP-IPV/Hib in a single injection, while another group concurrently received DTaP-IPV and Hib at separate injection sites. Solicited adverse events were monitored by parental observation and were recorded on a diary card. Levels of serum antibodies to DTaP and polyribosyl-ribitolphosphate-tetanus (PRP-T) antigens were collected before the first vaccine dose and 1 month after the third vaccine dose.

RESULTS:

The combined-injection group tended to have lower local reactions, and there was no increase in reactogenicity when compared with the separate-injection group. Seroconversion rates were 100% in both groups for all antigens, except for the anti-polio 2 antibody in the combined-injection group (96.4%). The combined-injection group had lower antibody levels of PRP (8.45 microg/ml) than did the separate-injection group (20.61 microg/ml). However, the percentage of vaccines achieving protective levels of antibody to PRP (> or = 0.15 microg/ml or > or = 1.0 microg/ml) was similar in both groups.

CONCLUSIONS:

DTaP-IPV/Hib may be safely and effectively administered to healthy infants, using a 2-, 4-, and 6-month vaccination schedule. This combined vaccine is cost-effective, more acceptable to parents and physicians, and minimizes distress to infants.

• Authors: Tzou-Yien Lin, Ying-Hsiang Wang, Luan-Yin Chang, Cheng-Hsun Chiu, Yhu-Chering Huang, Haiwen Tang, Hans L Bock
• Journal: Chang Gung medical journal (Chang Gung Med J) Vol. 26 Issue 5 Pg. 315-22 (May 2003) ISSN: 2072-0939 [Print] China (Republic : 1949- )
• PMID: 12934847 (Publication Type: Journal Article)

Chemical References

• Antibodies, Bacterial
• Diphtheria-Tetanus-acellular Pertussis Vaccines
• Haemophilus Vaccines
• Haemophilus influenzae type b polysaccharide vaccine
• Poliovirus Vaccine, Inactivated
• Polysaccharides, Bacterial
• Vaccines, Combined

Topics

• Antibodies, Bacterial (immunology)
• Bacterial Capsules
• Diphtheria-Tetanus-acellular Pertussis Vaccines (immunology)
• Haemophilus Vaccines
• Haemophilus influenzae type b (immunology)
• Humans
• Infant
• Poliovirus Vaccine, Inactivated (immunology)
• Polysaccharides, Bacterial
• Taiwan
• Vaccination
• Vaccines, Combined (administration & dosage, immunology)