Abstract | UNLABELLED: Acute alkalosis may directly affect PTH secretion. The effect of acute metabolic and respiratory alkalosis was studied in 20 dogs. PTH values were lower in the metabolic (5.6 +/- 0.8 pg/ml) and respiratory (1.8 +/- 0.6 pg/ml) alkalosis groups than in the control group (27 +/- 5 pg/ml). Acute alkalosis is an independent factor that decreases PTH values during normocalcemia and delays the PTH response to hypocalcemia. INTRODUCTION: MATERIALS AND METHODS: RESULTS: After 60 minutes of a normocalcemic clamp, PTH values were less (p < 0.05) in the metabolic (5.6 +/- 0.8 pg/ml) and respiratory (1.8 +/- 0.6 pg/ml) alkalosis groups than in the control group (27 +/- 5 pg/ml); the respective blood pH values were 7.61 +/- 0.01, 7.59 +/- 0.02, and 7.39 +/- 0.02. The maximal PTH response to hypocalcemia was similar among the three groups. However, the maximal PTH response was observed after a decrease in ionized calcium of 0.20 mM in the control group but not until a decrease of 0.40 mM in the metabolic and respiratory alkalosis groups. In contrast to the metabolic alkalosis group, hypernatremia (157 +/- 2 mEq/liter) in the hypertonic saline group was associated with an increased PTH value (46 +/- 4 pg/ml). Finally, the half-life of intact PTH was not different among the control and two alkalosis groups. CONCLUSIONS:
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Authors | Ignacio Lopez, Mariano Rodriguez, Arnold J Felsenfeld, Jose Carlos Estepa, Escolastico Aguilera-Tejero |
Journal | Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
(J Bone Miner Res)
Vol. 18
Issue 8
Pg. 1478-85
(Aug 2003)
ISSN: 0884-0431 [Print] United States |
PMID | 12929937
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Parathyroid Hormone
- Phosphates
- Sodium
- Calcium
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Topics |
- Acute Disease
- Alkalosis, Respiratory
(blood, physiopathology)
- Animals
- Calcium
(blood, pharmacology)
- Dogs
- Half-Life
- Hydrogen-Ion Concentration
- Parathyroid Hormone
(blood, metabolism)
- Phosphates
(blood)
- Sodium
(blood)
- Time Factors
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