Bromocriptine-responsive akinetic mutism following endoscopy for ventricular neurocysticercosis. Case report and review of the literature.

Abstract

A 26-year-old woman with obstructive hydrocephalus caused by a cysticercal cyst blocking the left foramen of Monro was initially treated with an external ventriculostomy and subsequent endoscopically assisted cyst resection and septostomy. Postoperatively, the patient developed the clinical syndrome of akinetic mutism, but her condition improved after the administration of the dopaminergic agonist bromocriptine. This result indicates that a disruption in the ascending dopaminergic pathway involved in behavior formation was likely the cause of these neurological symptoms.

• Authors: Thomas Psarros, Alexander Zouros, Caetano Coimbra
• Journal: Journal of neurosurgery (J Neurosurg) Vol. 99 Issue 2 Pg. 397-401 (Aug 2003) ISSN: 0022-3085 [Print] United States
• PMID: 12924716 (Publication Type: Case Reports, Journal Article)

Chemical References

• Dopamine Agonists
• Bromocriptine

Topics

• Adult
• Akinetic Mutism (diagnosis, drug therapy, etiology)
• Bromocriptine (therapeutic use)
• Cerebral Ventricles (parasitology, pathology, surgery)
• Dopamine Agonists (therapeutic use)
• Endoscopy (adverse effects)
• Female
• Humans
• Magnetic Resonance Imaging
• Neurocysticercosis (complications, diagnosis, surgery)
• Neurosurgical Procedures (methods)
• Tomography, X-Ray Computed