Abstract | OBJECTIVE: At present there are no well-established pharmacological approaches in the management of post- cholecystectomy alkaline reactive gastritis. The aim of this study was to assess the effect of sucralfate versus rabeprazole or no treatment on dyspeptic symptoms and endoscopic/histological signs in a population of patients with a history of cholecystectomy and evidence of alkaline reactive gastritis. METHODS: Sixty dyspeptic patients fulfilling the following criteria of inclusion took part in this study: (1) a history of cholecystectomy; (2) no use of anti-inflammatory steroidal and non-steroidal drugs, or abuse of alcohol; (3) evidence of abundant gastric bile reflux at endoscopy; (4) endoscopic signs of chronic gastritis; (5) histological signs of chronic gastritis; and (6) absence of Helicobacter pylori infection. Dyspeptic symptoms were evaluated by means of a self-administered validated questionnaire. Patients included in the study were randomly assigned to one of three treatment groups for 3 months: sucralfate, rabeprazole, observation. Patients were re-evaluated at the end of the treatment. RESULTS: CONCLUSION:
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Authors | Luca Santarelli, Maurizio Gabrielli, Marcello Candelli, Filippo Cremonini, Enrico C Nista, Giovanni Cammarota, Giovanni Gasbarrini, Antonio Gasbarrini |
Journal | European journal of gastroenterology & hepatology
(Eur J Gastroenterol Hepatol)
Vol. 15
Issue 9
Pg. 975-9
(Sep 2003)
ISSN: 0954-691X [Print] England |
PMID | 12923369
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- 2-Pyridinylmethylsulfinylbenzimidazoles
- Anti-Ulcer Agents
- Benzimidazoles
- Rabeprazole
- Sucralfate
- Omeprazole
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Topics |
- 2-Pyridinylmethylsulfinylbenzimidazoles
- Adult
- Aged
- Analysis of Variance
- Anti-Ulcer Agents
(therapeutic use)
- Benzimidazoles
(therapeutic use)
- Cholecystectomy
(adverse effects)
- Duodenogastric Reflux
(complications)
- Dyspepsia
(drug therapy, etiology)
- Female
- Gastritis
(drug therapy, etiology, pathology)
- Gastroscopy
- Humans
- Male
- Middle Aged
- Omeprazole
(analogs & derivatives)
- Pilot Projects
- Rabeprazole
- Statistics, Nonparametric
- Sucralfate
(therapeutic use)
- Treatment Outcome
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