Abstract | BACKGROUND: OBJECTIVES: To analyse the long term outcome of patients with ReA, treated with a three month course of ciprofloxacin or placebo. METHODS: Patients who had had ReA and had participated in a double blind, placebo controlled trial on the effectiveness of ciprofloxacin 4-7 years earlier were invited to a clinical examination. Of the 71 patients who were included in the original study, 53 agreed to visit the clinic for an examination. Twenty six of 53 patients had originally received ciprofloxacin and 27 had belonged to the placebo group. Of these, 20 in the ciprofloxacin and 25 in the placebo group were HLA-B27 positive. RESULTS: CONCLUSION: Analysis 4-7 years after the initial ReA suggests that a three month course of antibiotics in the acute phase may have a beneficial effect on the long term prognosis.
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Authors | T Yli-Kerttula, R Luukkainen, U Yli-Kerttula, T Möttönen, M Hakola, M Korpela, M Sanila, J Uksila, A Toivanen |
Journal | Annals of the rheumatic diseases
(Ann Rheum Dis)
Vol. 62
Issue 9
Pg. 880-4
(Sep 2003)
ISSN: 0003-4967 [Print] England |
PMID | 12922963
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Infective Agents
- HLA-B27 Antigen
- PHB2 protein, human
- Prohibitins
- Ciprofloxacin
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Topics |
- Acute Disease
- Adult
- Aged
- Anti-Infective Agents
(therapeutic use)
- Arthritis, Reactive
(drug therapy)
- Chronic Disease
- Ciprofloxacin
(therapeutic use)
- Double-Blind Method
- Drug Administration Schedule
- Female
- Follow-Up Studies
- HLA-B27 Antigen
(blood)
- Humans
- Male
- Middle Aged
- Prognosis
- Prohibitins
- Rheumatic Diseases
(immunology, prevention & control)
- Treatment Outcome
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